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KMID : 0391119950040020062
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Ulsan University Medical Journal
1995 Volume.4 No. 2 p.62 ~ p.69
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Laryngeal transplantation in the rat
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Abstract
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Differing from other organs, the success of vascular reanastomosis and functional reinnervation including voice are important to laryngeal transplantation, 26 cases of the Wister rat(250-300gm) were performed. The donor's right common carotid and
recipient's left common carotid artery were connected by 8 stitches 10.0 prolene. The donor's left common carotid artery and recipient's left external jugular vein were connected by 6 stitches 10.0 prolene. The recurrent laryngeal nerves were
connected
by 1 stitch 10.0 prolene. The last two cases which showed reinnervation were connected by 1 stitch with vein graft.
@ES The results were as follows;
@EN 1) 2 cases died within 2 hours.
2) 4 cases died within 2 weeks.
3) 13 cases which can be followed for 3 monthes.
7 cases lost donor larynx.
3 cases showed severe muscular atrophy.
1 case showed intact external apperance. But did not reinnervated.
The last 2 cases showed spontaneous movement and reinnervation was identified through glycogen depletion and elctromyography.
This study will be a cornerstone preparing for human laryngeal transplantation.
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KEYWORD
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